在西方狼人家族的传说里，有着一个介于人类和纯种狼人之间的神秘种族——“剥皮行者”，他们行动迅猛，杀人成性，嗜好吸食人类血液，夜空中冉冉升起的血红月亮正是他们的象征。“剥皮行者”因其凶残受到人类诅咒，但随着种族的扩大与繁衍，其内部开始分化。
和母亲雷切尔（Rhona Mitra 罗拉·麦特拉 饰）相依为命的小男孩蒂莫西（Matthew Knight 马修·奈特 饰）即将迎来自己十三岁的生日，但他的命运却马上要发生改变。蒂莫西是人类和狼人的孩子，他拥有统治族群的强大能力。为了争夺种族控制权，嗜血凶残的一派和希望摆脱厄运诅咒的一派展开了殊死搏斗……
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